Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa.
| Autor: | Antoine Jaquet, Apollinaire Horo, Didier K Ekouevi, Badian Toure, Patrick A Coffie, Benjamin Effi, Severin Lenaud, Eugene Messou, Albert Minga, Annie J Sasco, François Dabis, IeDEA West Africa Collaboration |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 9, Iss 3, p e90625 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 45789525 |
| DOI: | 10.1371/journal.pone.0090625 |
| Popis: | Facing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance.A cervical cancer screening based on visual inspection methods was proposed to HIV-infected women in care in Abidjan, Côte d'Ivoire. Positively screened women were referred for a colposcopy to a gynaecologist who performed directed biopsies.Of the 2,998 HIV-infected women enrolled, 132 (4.4%) CIN of any grade (CIN+) were identified. Women had been followed-up for a median duration of three years [IQR: 1-5] and 76% were on antiretroviral treatment (ART). Their median most recent CD4 count was 452 [IQR: 301-621] cells/mm3. In multivariate analysis, CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2-0.6) or ≥200-350 cells/mm3 (OR 0.6; 95% CI 0.4-1.0) (Ref: |
| Databáze: | Directory of Open Access Journals |
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