N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide

Autor:	Paolo Coghi, Jerome P. L. Ng, Ali Adnan Nasim, Vincent Kam Wai Wong
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	1 2 3-triazole anticancer aminoquinoline hybrid compound Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2021, Iss 2, p M1213 (2021)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1213
Popis:	The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.
Databáze:	Directory of Open Access Journals
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