The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.

Autor: Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS Biology, Vol 20, Iss 7, p e3001710 (2022)
Druh dokumentu: article
ISSN: 1544-9173
1545-7885
DOI: 10.1371/journal.pbio.3001710
Popis: Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars. Here, we discover an unexpected nonneuronal function of Gr64 receptors and show that they promote proteostasis in epithelial cells affected by proteotoxic stress. Using heterozygous mutations in ribosome proteins (Rp), which have recently been shown to induce proteotoxic stress and protein aggregates in cells, we show that Rp/+ cells in Drosophila imaginal discs up-regulate expression of the entire Gr64 cluster and depend on these receptors for survival. We further show that loss of Gr64 in Rp/+ cells exacerbates stress pathway activation and proteotoxic stress by negatively affecting autophagy and proteasome function. This work identifies a noncanonical role in proteostasis maintenance for a family of gustatory receptors known for their function in neuronal sensation.
Databáze: Directory of Open Access Journals
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