Efficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy
| Autor: | Antonin Parízek, Patrik Šimják, Andrej Cerný, Alena Šestinová, Anna Zdenková, Martin Hill, Michaela Dušková, Martin Procházka, Radovan Vlk, Zuzana Kokrdová, Michal Koucký, Libor Vitek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Annals of Hepatology, Vol 15, Iss 5, Pp 757-761 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1665-2681 16652681 |
| DOI: | 10.5604/16652681.1212587 |
| Popis: | Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy.Material and methods. Our retrospective multicentric study was performed on 191 consecutive pregnant women with ICP treated with UDCA. Any maternal and/or fetal complications of the UDCA treatment were searched for; healthy pregnant women (n = 256) served as controls.Results. The UDCA treatment improved liver disease status in the majority of the affected women (86.1%). This treatment was well tolerated, with only negligible skin reactions (0.5%) and mild diarrhea (4.7%). No complications attributable to UDCA treatment were detected during the fetal life, delivery, or the early neonatal period.Conclusion. We confirmed the good efficacy and safety of UDCA treatment in pregnancy for both mothers and fetuses/neonates. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|