Association of LPL-Hind III polymorphism with coronary artery disease in Macedonian population
| Autor: | Georgiev Antonio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Sanamed, Vol 8, Iss 1, Pp 25-31 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1452-662X 2217-8171 |
| Popis: | Objective: Coronary artery disease (CAD) is a leading cause of high mortality and morbidity in worldwide. The Hind III polymorphism of the LPL gene (LPL-Hind III) is a common variant and has been associated with plasma lipid and lipoprotein variability in population studies. Aim: Evaluation of the LPL-Hind III polymorphism as an independent risk factor for coronary artery disease in Macedonian population. Material and Methods: A polymerase chain reaction amplification and consecutive restriction enzyme digestion was used to reveal lipoprotein lipase, the intron 8 LPL-Hind III polymorphism. Study group included 114 randomized subjects with angiographically documented coronary artery stenosis (CAD group: 87 males, 27 females). Control group consisted of 35 patients (21 males and 14 females) without significant stenosis in coronary arteries. Results: Independent multiple regression analysis of LDL plasma level and their correlation with LPL-Hind III polymorphism and analyzed risk factors: hypertension, diabetes, family history of CAD, physical activity, antilipidemic drugs and alcohol consumption, LDL, show statistically significant correlation with BMI, and also between LPL-Hind III and LDL plasma level. In the examined group, only triglycerides reached a statistically significant association with the LPL-Hind III polymorphism. Conclusion: In our study, the LPL-Hind III polymorphism was not identified as independent risk factor for CAD, but showed association with high triglycerides and LDL levels. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|