| Autor: |
Carolina Barbosa Ribeiro, Daiane Cristina Christofoletti, Vitor Alexandre Pezolato, Rita de Cassia Marqueti, Jonato Prestes, Ramires Alsamir Tibana, Elaine Cristina Leite Pereira, Ivo Vieira de Sousa Neto, João Luiz Quagliotti Durigan, Carlos Alberto da Silva |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Frontiers in Physiology, Vol 6 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2015.00073 |
| Popis: |
The aim of the present study was to evaluate the effect of leucine treatment (0.30 mM) on muscle weight and signaling of myoproteins related to synthesis and degradation pathways of soleus muscle following seven days of complete sciatic nerve lesion.Wistar rats (n=24) of 3 to 4 months of age (192 ± 23 g) were used. The animals were randomly distributed into four experimental groups (n=6/group): control, treated with leucine (L), denervated (D) and denervated treated with leucine (DL).Dependent measures were proteins levels of AKT, AMPK, mTOR, and ACC performed by Western blot. Leucine induced a reduction in the phosphorylation of AMPK (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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