Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction

Autor: Alberto Cecconi, Gonzalo Navarrete, Marcos Garcia-Guimaraes, Alberto Vera, Rafael Blanco-Dominguez, Ancor Sanz-Garcia, Marta Lozano-Prieto, Beatriz Lopez-Melgar, Fernando Rivero, Pilar Martin, Francisco Sanchez-Madrid, Hortensia de la Fuente, Luis Jesus Jimenez-Borreguero, Fernando Alfonso
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-09383-7
Popis: Abstract Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.
Databáze: Directory of Open Access Journals
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