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Yanjuan Song,1 Jing Hu,2 Chunlian Ma,3– 5 Hua Liu,3– 5 Zhanghua Li,6 Yi Yang3– 5 1Graduate School, Wuhan Sports University, Wuhan, Hubei Province, People’s Republic of China; 2Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei Province, People’s Republic of China; 3Fitness Monitoring and Chronic Disease Intervention Research Center, Wuhan Sports University, Wuhan, Hubei Province, People’s Republic of China; 4College of Sports Medicine, Wuhan Sports University, Wuhan, Hubei Province, People’s Republic of China; 5Hubei Key Laboratory of Exercise Training and Monitoring, Wuhan Sports University, Wuhan, Hubei Province, People’s Republic of China; 6Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of ChinaCorrespondence: Yi Yang, Fitness Monitoring and Chronic Disease Intervention research center, Wuhan Sports University, Wuhan, Hubei Province, 430079, People’s Republic of China, Tel +86 139 7129 3990, Email yangyi999999@foxmail.com Zhanghua Li, Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, 430074, People’s Republic of China, Tel +86 189 7161 0121, Email lizhanghua_123@163.comAbstract: The development of numerous diseases is significantly influenced by inflammation. Macrophage-derived exosomes (M-Exos) play a role in controlling inflammatory reactions in various conditions, including chronic inflammatory pain, hypertension, and diabetes. However, the specific targets and roles of M-Exos in regulating inflammation in diseases remain largely unknown. This review summarizes current knowledge on M-Exos biogenesis and provides updated information on M-Exos’ biological function in inflammation modulation. Furthermore, this review highlights the functionalization and engineering strategies of M-Exos, while providing an overview of cutting-edge approaches to engineering M-Exos and advancements in their application as therapeutics for inflammation modulation. Finally, multiple engineering strategies and mechanisms are presented in this review along with their perspectives and challenges, and the potential contribution that M-Exos may have in diseases through the modulation of inflammation is discussed.Keywords: inflammation, macrophage-derived exosomes, biological functions, inflammation modulation, engineering strategies |
