| Autor: |
Shailesh S. Gurav, Krishnakant T. Waghmode, Shweta N. Dandekar, Siddheshwar D. Jadhav, Onkar A. Lotlikar, Seema R. Jadhav, Suraj N. Mali, Jayashri G. Naphade |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Chemical Physics Impact, Vol 8, Iss , Pp 100494- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0224 |
| DOI: |
10.1016/j.chphi.2024.100494 |
| Popis: |
The novel 1-(2-chloroimidazo[1,2-a]pyridin-3-yl)-N-(substitutedphenyl) methanimines have been synthesized and characterized by spectral (IR, MS, 1H, and 13C NMR) and elemental analysis. Molecular docking studies were conducted with three cancer target proteins (PDB IDs: 1M17, 2OF4, and 3LCK) and assorted microbial target proteins (1KZN, 2XCT, 1D7U, 1BAG, and 1EA1) to explore their binding interactions. Further in-silico target prediction study suggested a 26.7 % probability that VIf acts on kinases. The synthesized analogs were subjected to in-vitro anticancer activity assessments against A-498 (kidney carcinoma) and A-549 (lung carcinoma) cell lines and compound VIf exhibited good inhibition (GI50 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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