Prevalence and Prognosis of Portopulmonary Hypertension in 223 Liver Transplant Recipients

Autor: Jian Li, Qi Zhuang, Xueming Zhang, Ying Zheng, Zhiqing Qiao, Jianjun Zhang, Xuedong Shen, Jieyan Shen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Canadian Respiratory Journal, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1198-2241
1916-7245
45130639
DOI: 10.1155/2018/9629570
Popis: Objective. To investigate the prevalence and prognosis of portopulmonary hypertension (PoPH) in liver transplant recipients. Methods. Patients with advanced liver disease who underwent orthotopic liver transplantation (OLT) were included in this retrospective study from January 2012 to June 2015. According to the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines for the diagnosis of pulmonary hypertension (PH), patients with tricuspid regurgitation velocity (TRV) >3.4 m/s or 2.9 m/s ≤ TRV ≤ 3.4 m/s coexisting with other echocardiographic PH signs were judged as PH. PH patients with portal hypertension and without other known causes of PH were diagnosed as PoPH. Results. A total of 223 (170 males and 53 females) middle-aged (50.9 ± 9 years old) liver transplant recipients were included in this study. Fourteen patients (6.3%) were diagnosed with PoPH, and none of the patients were treated with vasodilators before or after OLT. After OLT, patients were followed up for 26 ± 13.5 months. In total, 8 of 14 (57%) PoPH patients died, and the main cause of death was pulmonary infection. Kaplan–Meier survival curves revealed a significant difference in survival between PoPH and non-PoPH patients (p
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