Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Autor: Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden, Esperanza Herreros
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms15160
Popis: There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.
Databáze: Directory of Open Access Journals