Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model

Autor:	Heinig Leo, Markus Kipp
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	cuprizone multiple sclerosis remyelination demyelination progression protection Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 23, Iss 24, p 16093 (2022)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms232416093
Popis:	Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/45037235cd174f1abd5f4b98fd14612c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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