Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event

Autor: Nicolas Gallastegui, Daniel P. Cassidy, Deborah O. Heros, Francisco Vega, Jonathan H. Schatz
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Case Reports in Hematology, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2090-6560
2090-6579
DOI: 10.1155/2019/1825491
Popis: Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes.
Databáze: Directory of Open Access Journals
Externí odkaz: