A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population

Autor: Buthaina E. Alathari, Dhanasekaran Bodhini, Ramamoorthy Jayashri, Nagarajan Lakshmipriya, Coimbatore Subramanian Shanthi Rani, Vasudevan Sudha, Julie A. Lovegrove, Ranjit Mohan Anjana, Viswanathan Mohan, Venkatesan Radha, Rajendra Pradeepa, Karani S. Vimaleswaran
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nutrients, Vol 12, Iss 5, p 1357 (2020)
Druh dokumentu: article
ISSN: 12051357
2072-6643
DOI: 10.3390/nu12051357
Popis: Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D] concentrations. We investigate whether this relationship was modified by lifestyle factors using a nutrigenetic approach in 545 Asian Indians randomly selected from the Chennai Urban Rural Epidemiology Study (219 normal glucose tolerant individuals, 151 with pre-diabetes and 175 individuals with type 2 diabetes). A metabolic genetic risk score (GRS) was developed using five common metabolic disease-related genetic variants. There was a significant interaction between metabolic GRS and carbohydrate intake (energy%) on 25(OH)D (Pinteraction = 0.047). Individuals consuming a low carbohydrate diet (≤62%) and those having lesser number of metabolic risk alleles (GRS ≤ 1) had significantly higher levels of 25(OH)D (p = 0.033). Conversely, individuals consuming a high carbohydrate diet despite having lesser number of risk alleles did not show a significant increase in 25(OH)D (p = 0.662). In summary, our findings show that individuals carrying a smaller number of metabolic risk alleles are likely to have higher 25(OH)D levels if they consume a low carbohydrate diet. These data support the current dietary carbohydrate recommendations of 50%–60% energy suggesting that reduced metabolic genetic risk increases 25(OH)D.
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