The regulation of simulated artificial oro-gastrointestinal transit stress on the adhesion of Lactobacillus plantarum S7

Autor: Dawei Chen, Chunmeng Chen, Congcong Guo, Hui Zhang, Yating Liang, Yue Cheng, Hengxian Qu, Yunchao Wa, Chenchen Zhang, Chengran Guan, Jianya Qian, Ruixia Gu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-16 (2023)
Druh dokumentu: article
ISSN: 1475-2859
DOI: 10.1186/s12934-023-02174-3
Popis: Abstract Background Oro-gastrointestinal stress in the digestive tract is the main stress to which orally administered probiotics are exposed. The regulation of oro-gastrointestinal transit (OGT) stress on the adhesion and survival of probiotics under continuous exposure to simulated salivary-gastric juice-intestinal juice was researched in this study. Results Lactobacillus plantarum S7 had a higher survival rate after exposure to simulated OGT1 (containing 0.15% bile salt) stress and OGT2 (containing 0.30% bile salt) stress. The adhesion ability of L. plantarum S7 was significantly increased by OGT1 stress (P 0.05), and this trend was also observed in terms of the thickness of the surface material of L. plantarum S7 cells. The expression of surface proteins of L. plantarum S7, such as the 30 S ribosomal proteins, mucus-binding protein and S-layer protein, was significantly downregulated by OGT stress (P
Databáze: Directory of Open Access Journals
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