Localization and expression of two human b-defensins (HBD-1 and HBD-2) in intestinal biopsies of celiac patients
| Autor: | M Boniotto, D Pirulli, MV Verga Falzacappa, C Trevisiol, T Gerarduzzi, S Crovella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | European Journal of Histochemistry, Vol 47, Iss 4 (2009) |
| Druh dokumentu: | article |
| ISSN: | 1121-760X 2038-8306 |
| DOI: | 10.4081/852 |
| Popis: | Innate immunity is the first line of defense against microorganisms in vertebrates and acts by providing an initial barrier to microorganisms and triggering adaptive immune responses (Ganz and Lehrer 1999; Oppenheim et al., 2002). Peptides such as b-defensins are an important component of this defense, both providing a broad spectrum of antimicrobial activity against bacteria, fungi, mycobacteria and several enveloped viruses (Ganz and Leher, 1994) and showing chemotactic activity by linking and activating CCR6 (Hoover DM et al. , 2002). b-defensins are small cationic peptides that vary in their expression patterns and spectrum of pathogen specificity (Ganz and Leher, 2002). |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|