| Autor: |
Ariadni Bella, Alba M. Diego, David P. Finn, Michelle Roche |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Pain Research, Vol 3 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-561X |
| DOI: |
10.3389/fpain.2022.1106143 |
| Popis: |
Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main risk factors for the development of chronic post-surgical pain. Clinically valid animal models provide an important means of examining the mechanisms underlying the effects of stress on post-surgical pain and identifying potential novel therapeutic targets. This review discusses the current data from preclinical animal studies examining the effect of stress on post-surgical pain, the potential underlying mechanisms and gaps in the knowledge that require further investigation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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