| Autor: |
Chao Tan, Fei Yan, Li-Ping Yao, Jun-Ling Xing, Wei-Jun Qin, Kun Zhang, Guo-Jun Wu, Jian-Lin Yuan, Fei Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
BMC Urology, Vol 20, Iss 1, Pp 1-12 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2490 |
| DOI: |
10.1186/s12894-020-00698-z |
| Popis: |
Abstract Background To investigate the functions of the hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells in a rat model of overactive bladder syndrome. Methods Rats with OAB were screened using a urodynamic testing device. The whole-cell patch clamp technique was used to investigate changes in excitability and hyperpolarization-activated cation current (I h) of medium-size cells in the L6 dorsal root ganglia (DRG) of the OAB rats. Intrathecal injection of the specific I h inhibitor ZD7288 was used to investigate changes of voiding function and I h of medium-size cells in the L6 DRG. Results The urinary bladder weight of the OAB rats was significantly increased (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink