MAMMALIAN MODELS OF PATHOGEN-ASSOCIATED MUSCLE DEGENERATION

Autor: John Sylvester Nas, Trisha Jaden Galang, Anlie Bacod, Cher Agape Cervantes, Jubilee Ivy Estrilles, Rheaa Esguera, Ryan Miguel Milleza, Paula Angeli Servino, Laarni Hannah Lacorte
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Exploratory Animal and Medical Research, Vol 12, Iss 2, Pp 134-148 (2022)
Druh dokumentu: article
ISSN: 2277-470X
2319-247X
DOI: 10.52635/eamr/12.2.134-148
Popis: Studies on pathogen-associated muscle degeneration (PAMD) seem not to progress despite the recent advancements in omics. The limited and outdated literature about pathogen-associated muscle degeneration in different animal models contradicts the thorough understanding of their genome. In this paper, we review the pathophysiology of pathogen infection through association with the physiologic, biochemical, and molecular changes happening in the skeletal, cardiac, and smooth muscles of different well-established mammalian models, namely rats (Rattus sp.), mice (Mus musculus), and rabbit (Oryctolagus cuniculus). The use of model organisms is beneficial to the advances in muscle degeneration research since they are inexpensive, low maintenance, and can be used for genetic screenings. This review illuminated an understanding of the potential application of well-established model organisms in advancing the current knowledge about pathogen-associated muscle degeneration.
Databáze: Directory of Open Access Journals
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