Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma

Autor: Tomonori Kaneko, Peter Y. F. Zeng, Xuguang Liu, Rober Abdo, John W. Barrett, Qi Zhang, Anthony C. Nichols, Shawn Shun-Cheng Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Medicine, Vol 2, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2730-664X
DOI: 10.1038/s43856-022-00159-8
Popis: Kaneko et al. compare the proteome and phosphoproteome of primary HPV + oropharyngeal squamous cell cancers with tumours that recurred following chemotherapy/radiation. The authors identify signatures of fibrosis, matrix remodeling, and epithelial-mesenchymal transition and reprogrammed cytoskeletal signalling in recurrent tumours.
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