| Autor: |
Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Anders K. Nilsson, Joakim C. Ek, Hanna Danielsson, Pernilla Svedin, Milos Pekny, Marcela Pekna, Karin Sävman, Ann Hellström, Carina Mallard |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 7, Pp 107217- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.107217 |
| Popis: |
Summary: Staphylococcus (S.) epidermidis is the most common nosocomial coagulase-negative staphylococci infection in preterm infants. Clinical signs of infection are often unspecific and novel markers to complement diagnosis are needed. We investigated proteomic alterations in mouse brain after S. epidermidis infection and in preterm infant blood. We identified lipocalin-2 (LCN2) as a crucial protein associated with cerebrovascular changes and astrocyte reactivity in mice. We further proved that LCN2 protein expression was associated with endothelial cells but not astrocyte reactivity. By combining network analysis and differential expression approaches, we identified LCN2 linked to blood C-reactive protein levels in preterm infants born |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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