| Autor: |
Joseph E Ebinger, Natalie Achamallah, Hongwei Ji, Brian L Claggett, Nancy Sun, Patrick Botting, Trevor-Trung Nguyen, Eric Luong, Elizabeth H Kim, Eunice Park, Yunxian Liu, Ryan Rosenberry, Yuri Matusov, Steven Zhao, Isabel Pedraza, Tanzira Zaman, Michael Thompson, Koen Raedschelders, Anders H Berg, Jonathan D Grein, Paul W Noble, Sumeet S Chugh, C Noel Bairey Merz, Eduardo Marbán, Jennifer E Van Eyk, Scott D Solomon, Christine M Albert, Peter Chen, Susan Cheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 15, Iss 7, p e0236240 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0236240 |
| Popis: |
ImportanceCertain individuals, when infected by SARS-CoV-2, tend to develop the more severe forms of Covid-19 illness for reasons that remain unclear.ObjectiveTo determine the demographic and clinical characteristics associated with increased severity of Covid-19 infection.DesignRetrospective observational study. We curated data from the electronic health record, and used multivariable logistic regression to examine the association of pre-existing traits with a Covid-19 illness severity defined by level of required care: need for hospital admission, need for intensive care, and need for intubation.SettingA large, multihospital healthcare system in Southern California.ParticipantsAll patients with confirmed Covid-19 infection (N = 442).ResultsOf all patients studied, 48% required hospitalization, 17% required intensive care, and 12% required intubation. In multivariable-adjusted analyses, patients requiring a higher levels of care were more likely to be older (OR 1.5 per 10 years, PConclusions and relevanceIn our healthcare system, greater Covid-19 illness severity is seen in patients who are older, male, African American, obese, with diabetes, and with greater overall comorbidity burden. Certain comorbidities paradoxically augment risk to a greater extent in younger patients. In hospitalized patients, male sex is the main determinant of needing more intensive care. Further investigation is needed to understand the mechanisms underlying these findings. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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