In vivo evaluation of an innovative synbiotics on stage IIIb-IV chronic kidney disease patients

Autor: Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese, Maria Teresa Rocchetti, Ilaria Iacobellis, Nadia Serale, Maria Calasso, Loreto Gesualdo, Maria De Angelis
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Nutrition, Vol 10 (2023)
Druh dokumentu: article
ISSN: 2296-861X
DOI: 10.3389/fnut.2023.1215836
Popis: BackgroundMicrobiota unbalance has been proven to affect chronic kidney disease (CKD) patients and, noteworthy, microbiota composition and activity are implicated in CKD worsening. The progression of kidney failure implies an exceeding accumulation of waste compounds deriving from the nitrogenous metabolism in the intestinal milieu. Therefore, in the presence of an altered intestinal permeability, gut-derived uremic toxins, i.e., indoxyl sulfate (IS) and p-cresyl sulfate (PCS), can accumulate in the blood.MethodsIn a scenario facing the nutritional management as adjuvant therapy, the present study assessed the effectiveness of an innovative synbiotics for its ability to modulate the patient gut microbiota and metabolome by setting a randomized, single-blind, placebo-controlled, pilot trial accounting for IIIb-IV stage CKD patients and healthy controls. Metataxonomic fecal microbiota and fecal volatilome were analyzed at the run-in, after 2 months of treatment, and after 1 month of wash out.ResultsSignificant changes in microbiota profile, as well as an increase of the saccharolytic metabolism, in feces were found for those CKD patients that were allocated in the synbiotics arm.ConclusionsNoteworthy, the here analyzed data emphasized a selective efficacy of the present synbiotics on a stage IIIb-IV CKD patients. Nonetheless, a further validation of this trial accounting for an increased patient number should be considered.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT03815786.
Databáze: Directory of Open Access Journals