Bone marrow aspirate concentrate with cancellous allograft versus iliac crest bone graft in the treatment of long bone nonunions
| Autor: | Kenneth Lin, MD, James VandenBerg, BS, Sara M. Putnam, MD, Christopher D. Parks, MD, Amanda Spraggs-Hughes, MA, Christopher M. McAndrew, MD, MSc, William M. Ricci, MD, Michael J. Gardner, MD |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | OTA International, Vol 2, Iss 1, p e012 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2574-2167 00000000 |
| DOI: | 10.1097/OI9.0000000000000012 |
| Popis: | Abstract. Objectives:. The purpose of this study was to compare bone marrow aspirate concentrate (BMAC) with cancellous allograft to iliac crest bone graft (ICBG) in the treatment of long bone nonunions. Design:. Retrospective cohort study. Setting:. A single level I trauma center. Patients:. 26 patients with long bone diaphyseal or metaphyseal nonunions with defects >2 mm and treated with open repair and BMAC, compared to 25 patients with long bone diaphyseal or metaphyseal nonunions with defects >2 mm and treated with open repair and ICBG. Intervention:. Open repair of long bone nonunion using either autologous ICBG or BMAC with cancellous allograft. Main outcome measure:. Nonunion healing, radiographically measured by the modified Radiographic Union Score for Tibia (mRUST) score. Secondary outcomes included risk factors associated with failed repair. Results:. The union rates for the BMAC and ICBG cohorts were 75% and 78%, respectively (P = .8). Infection was the only risk factor of statistical significance for failure. Conclusion:. In this study, we found no significant difference in union rate for long bone nonunions treated with ICBG or BMAC with allograft. BMAC and allograft led to 75% successful healing in this series. Given the heterogeneity of the control group and loss to follow-up, further prospective investigation should be conducted to more rigorously compare BMAC to ICBG for nonunion treatment. Level of evidence:. III, retrospective cohort. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|