| Autor: |
Yu Wang, Yi Lu, Meimei Du, Nimo Mohamed Hussein, Lan Li, Chuanwan Mao, Tao Chen, Fangfang Chen, Xiaozheng Liu, Zhihan Yan, Yuchuan Fu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neurology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2295 |
| DOI: |
10.3389/fneur.2022.834458 |
| Popis: |
BackgroundParental migration has been associated with a higher risk of cognitive and behavioral abnormalities in left-behind children (LBC). This study aimed to explore the spontaneous brain activity in LBC and reveal the mechanisms underlying behavioral and cognitive abnormalities.MethodsInvolved LBC (n = 36) and non-LBC (n = 22) underwent resting-state functional MRI (fMRI) examination and cognitive and behavioral assessment. The fMRI-based amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were assessed to analyze the spontaneous brain activity pattern. The relationships among abnormal spontaneous brain activity, behavioral and cognitive deficits and altered family environment were assessed by partial correlation analysis.ResultsCompared with non-LBC, LBC exhibited increased amplitude of low-frequency fluctuations in the right lingual gyrus (LING), while a decreased ALFF was observed in the bilateral insula and right orbital part of the middle frontal gyrus (ORBmid) (two-tailed voxel-level p < 0.01 and cluster-level p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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