Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

Autor: Jiahui Cao, Manuel Ehling, Sigrid März, Jochen Seebach, Katsiaryna Tarbashevich, Tomas Sixta, Mara E. Pitulescu, Ann-Cathrin Werner, Boris Flach, Eloi Montanez, Erez Raz, Ralf H. Adams, Hans Schnittler
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-02373-8
Popis: The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation.
Databáze: Directory of Open Access Journals