B-Cell Responses to Sars-Cov-2 mRNA Vaccines

Autor: Lela Kardava, Clarisa Buckner, Susan Moir
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pathogens and Immunity, Vol 7, Iss 2 (2022)
Druh dokumentu: article
ISSN: 2469-2964
DOI: 10.20411/pai.v7i2.550
Popis: Most vaccines against viral pathogens protect through the acquisition of immunological memory from long-lived plasma cells that produce antibodies and memory B cells that can rapidly respond upon an encounter with the pathogen or its variants. The COVID-19 pandemic and rapid deployment of effective vaccines have provided an unprecedented opportunity to study the immune response to a new yet rapidly evolving pathogen. Here we review the scientific literature and our efforts to understand antibody and B-cell responses to SARS-CoV-2 vaccines, the effect of SARS-CoV-2 infection on both primary and secondary immune responses, and how repeated exposures may impact outcomes.
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