The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance

Autor:	Nadine Royla, Stefan Kempa
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	drug resistance cancer metabolism glutamine post-transcriptional regulation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 4 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2017.1338209
Popis:	Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4443e2710bf34012aea8011ebfc1e76d Zobrazit plný text záznamu View record in DOAJ