Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study

Autor: Caterina Rosano, Thomas K. Karikari, Ryan Cvejkus, Bruna Bellaver, Pamela C. L. Ferreira, Joseph Zmuda, Victor Wheeler, Tharick A. Pascoal, Iva Miljkovic
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2352-8737
DOI: 10.1002/trc2.12460
Popis: Abstract INTRODUCTION Alzheimer's disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers. METHODS In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau‐181 (p‐tau181), amyloid‐beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women. RESULTS Women were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age‐adjusted p
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