MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone

Autor: Sonat Pınar Kara, Gulsum Ozkan, Ahsen Yılmaz, Nergiz Bayrakçı, Savaş Güzel, Elif Geyik
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Renal Failure, Vol 43, Iss 1, Pp 676-683 (2021)
Druh dokumentu: article
ISSN: 0886-022X
1525-6049
0886022X
06795234
DOI: 10.1080/0886022X.2021.1915800
Popis: Aim MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone. Method Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the study. Patients’ demographic data were recorded, and office blood pressure measurement and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed. Blood specimens were collected for miRNA 21, miRNA 155 and aldosterone measurement. MiRNA 21 and miRNA 155 levels in the control and patient groups and their relations with other demographic and biochemical parameters were then subjected to analysis. Results No difference was determined in miRNA 155 levels between the groups, but miRNA 21 and aldosterone levels were significantly higher in the RH group (p
Databáze: Directory of Open Access Journals
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