Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution

Autor: Božinović Nina, Šolaja Bogdan A., Opsenica Igor M.
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of the Serbian Chemical Society, Vol 81, Iss 11, Pp 1225-1230 (2016)
Druh dokumentu: article
ISSN: 0352-5139
1820-7421
DOI: 10.2298/JSC160824074B
Popis: A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine). The procedure based on the double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation condition. [Projekat Ministarstva nauke Republike Srbije, br. 172008]
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