| Autor: |
Paul M. Macey, Janani P. Prasad, Jennifer A. Ogren, Ammar S. Moiyadi, Ravi S. Aysola, Rajesh Kumar, Frisca L. Yan-Go, Mary A. Woo, M. Albert Thomas, Ronald M. Harper |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
NeuroImage: Clinical, Vol 20, Iss , Pp 305-317 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2018.07.027 |
| Popis: |
Introduction: Obstructive sleep apnea (OSA) patients show hippocampal-related autonomic and neurological symptoms, including impaired memory and depression, which differ by sex, and are mediated in distinct hippocampal subfields. Determining sites and extent of hippocampal sub-regional injury in OSA could reveal localized structural damage linked with OSA symptoms. Methods: High-resolution T1-weighted images were collected from 66 newly-diagnosed, untreated OSA (mean age ± SD: 46.3 ± 8.8 years; mean AHI ± SD: 34.1 ± 21.5 events/h;50 male) and 59 healthy age-matched control (46.8 ± 9.0 years;38 male) participants. We added age-matched controls with T1-weighted scans from two datasets (IXI, OASIS-MRI), for 979 controls total (426 male/46.5 ± 9.9 years). We segmented the hippocampus and analyzed surface structure with “FSL FIRST” software, scaling volumes for brain size, and evaluated group differences with ANCOVA (covariates: total-intracranial-volume, sex; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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