Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency

Autor:	Said Abuhasna, Amer H Al Jundi
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Obese renal insufficiency vancomycin therapeutic drug monitoring Anesthesiology RD78.3-87.3 Pharmacy and materia medica RS1-441
Zdroj:	Journal of Anaesthesiology Clinical Pharmacology, Vol 27, Iss 4, Pp 531-533 (2011)
Druh dokumentu:	article
ISSN:	0970-9185 14026988
DOI:	10.4103/0970-9185.86601
Popis:	We report the pharmacokinetics of vancomycin in an obese patient with renal insufficiency using pharmacokinetic equations, and comparing them with actual levels. A 47-year-old man with morbid obesity had a complicated hospital course with acute renal failure. Due to sputum growth of coagulase-negative Staphylococcus aureus, vancomycin 1500 mg intravenously twice daily was given empirically. Peak and trough plasma concentrations were drawn at steady state. Based on levels, true pharmacokinetic parameters for the patient were calculated using equations. This revealed that calculating individual pharmacokinetic parameters using equations may be a valid tool for dosing vancomycin in obese patients with renal insufficiency.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/43ff452e24e140269883f882b267efcf Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF