Do All Antioxidant Supplements Have the Same Potential Effect on Preventing Myringosclerosis?
| Autor: | Seden Akdagli, Arzu Tuzuner, Sule Demirci, Hatice Karadas, Kamil Gökce Tulaci, Mehmet Dogan, Refik Caylan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Otorhinolaryngology, Vol 8, Iss 1, Pp 1-6 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1976-8710 2005-0720 |
| DOI: | 10.3342/ceo.2015.8.1.1 |
| Popis: | ObjectivesMyringosclerosis is an irreversible pathological healing mechanism of the tympanic membrane which can result in the formation of sclerotic plaques. Antioxidant treatment is a recognised prevention therapy and coenzyme Q10 (CoQ10), lycopene, and grape seed extract (GSE), were used in this manner.MethodsForty-four Wistar rats were used in this experiment, and, following myringotomies, the animals were randomly divided into four groups. CoQ10, lycopene or GSE was administered orally to the respective groups, starting from the day of surgery. Otomicroscopy examination was performed on the 14th day. All tympanic membrane lesions were evaluated and compared otomicroscopically and histopathologically.ResultsThe otomicroscopy and histopathological findings, compared against a control (saline) group, showed the CoQ10, lycopene, and GSE groups had statistically significant differences of degree of sclerosis (P |
| Databáze: | Directory of Open Access Journals |
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