| Autor: |
Eduardo de la Fuente-Munoz, Miguel Fernández-Arquero, Nabil Subbhi-Issa, Kissy Guevara-Hoyer, Lydia Pilar Suárez, Raquel Gil Laborda, Marina Sánchez, Juliana Ochoa-Grullón, María Guzmán-Fulgencio, Ángela Villegas, María Dolores Mansilla, Noelia Pérez, Ricardo Savirón Cornudella, Teresa Gastañaga-Holguera, Marta Calvo Urrutia, Ignacio Cristóbal García, Silvia Sánchez-Ramón |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1451552 |
| Popis: |
IntroductionThe prevalence of gluten-related disorders, mainly celiac disease (CD) and non-celiac gluten sensitivity (NCGS), varies between 0.6% and 13% in the general population. There is controversial evidence regarding the association of both CD and NCGS with extra-digestive manifestations, including recurrent reproductive failure (RRF), which may have clinical implications.ObjectiveTo study the prevalence of HLA susceptibility alleles for CD/NCGS in a cohort of female patients with RRF from a single reference center and to evaluate the effect of a gluten-free diet on reproductive success.Material and methodsA retrospective study was conducted on 173 patients with RRF, consecutively attended at the Reproductive Immunology Unit of San Carlos University Clinical Hospital in Madrid. We collected and analyzed the clinical, analytical, and immunological profiles of RRF patients who presented HLA alleles associated with CD and NCGS (HLA DQ2.2, DQ2.5, DQ8, and DQ7.5).ResultsWe observed a significantly higher prevalence of HLA alleles associated with CD and NCGS in our RRF cohort compared to the prevalence in the general population (69% vs. 35%–40%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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