Liver and Renal Cell Damage Following Excess Bee Honey Consumption in Male Wistar Rat
| Autor: | Akpevwoghene Agbatutu, Jerome Ndudi Asiwe, Olusegun Gafar Adebayo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biology, Medicine & Natural Product Chemistry, Vol 11, Iss 1, Pp 35-43 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2089-6514 2540-9328 |
| DOI: | 10.14421/biomedich.2022.111.35-43 |
| Popis: | Honey is a widely used natural product with several health benefits. However, there is paucity of information on its excessive usage. The present study investigated the effect of excess honey consumption on hepato-renal functions in male wistar rats. Twenty-eight adult male Wistar rats were selected into four groups (n=7) and treated with distilled water (control) and 1ml, 2ml and 3ml of honey respectively for 5 weeks. Thereafter, the animals were euthanised and blood as well as kidney and liver were collected for further studies. There was a significant increase in Creatinine, Bilirubin, Urea AST, ALP, total protein as well as a significant decrease in RBC, WBC, haemoglobin, lymphocyte and PCV. Histology of the liver and kidney revealed a significant degeneration and necrosis in a dose dependent manner. This study suggest that excess honey consumption causes liver and renal cellular damage as well as haematological alterations. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|