The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies

Autor:	Sophie Dithmer, Ingolf E. Blasig, Paul A. Fraser, Zhihai Qin, Reiner F. Haseloff
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	tight junction proteins blood-brain barrier tight junction structure cerebral disease claudins occludin Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 25, Iss 11, p 5601 (2024)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms25115601
Popis:	This review addresses the role of tight junction proteins at the blood-brain barrier (BBB). Their expression is described, and their role in physiological and pathological processes at the BBB is discussed. Based on this, new approaches are depicted for paracellular drug delivery and diagnostics in the treatment of cerebral diseases. Recent data provide convincing evidence that, in addition to its impairment in the course of diseases, the BBB could be involved in the aetiology of CNS disorders. Further progress will be expected based on new insights in tight junction protein structure and in their involvement in signalling pathways.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/43d17f313ca94cf78c055f388dbc319a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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