Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes

Autor: Raishi Ichikawa, Koji Takano, Kazumi Fujimoto, Masaki Kobayashi, Tadahiro Kitamura, Masayoshi Shichiri, Takeshi Miyatsuka
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 14, Iss 10, Pp 1172-1174 (2023)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.14053
Popis: Abstract Few studies in Asian populations have analyzed how glucagon secretion is affected by ingested glucose, proteins or lipids, individually. To investigate the fluctuations of glucagon secretion after the intake of each of these nutrients, 10 healthy volunteers underwent oral loading tests using each of glucose, proteins and lipids, and blood levels of glucose, insulin and glucagon were measured every 30 min for 120 min. Whereas glucagon secretion was suppressed and minimally affected by oral glucose intake and lipid intake, respectively, oral protein intake robustly increased glucagon secretion, as well as insulin secretion. Further studies are needed to elucidate the mechanism by which protein loading increases glucagon secretion.
Databáze: Directory of Open Access Journals
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