| Autor: |
Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Engineering, Vol 34, Iss , Pp 212-232 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2095-8099 |
| DOI: |
10.1016/j.eng.2023.11.011 |
| Popis: |
The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes. The Notch receptor is activated by two families of canonical ligands (Delta-like and Serrate/Jagged) where both ligands and receptors are single-pass transmembrane proteins usually with large extracellular domains, relative to their intracellular portions. Upon interaction of the core binding regions, presented on opposing cell surfaces, formation of the receptor/ligand complex initiates force-mediated proteolysis, ultimately releasing the transcriptionally-active Notch intracellular domain. This review focuses on structural features of the extracellular receptor/ligand complex, the role of post-translational modifications in tuning this complex, the contribution of the cell membrane to ligand function, and insights from acquired and genetic diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
