Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors

Autor:	R.C. Huang, P.E. Melton, M.A. Burton, L.J. Beilin, R Clarke-Harris, E Cook, K.M. Godfrey, G.C. Burdge, T.A. Mori, D Anderson, S. Rauschert, J. M. Craig, M.S. Kobor, J.L. MacIsaac, A.M. Morin, W.H. Oddy, C.E. Pennell, J.D. Holbrook, K.A. Lillycrop
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	dna methylation body composition inflammation high-sensitivity c-reactive protein adolescence youth leptin epigenetic variation maternal body mass index adiposity the raine study Genetics QH426-470
Zdroj:	Epigenetics, Vol 17, Iss 8, Pp 819-836 (2022)
Druh dokumentu:	article
ISSN:	1559-2294 1559-2308 15592294
DOI:	10.1080/15592294.2021.1876297
Popis:	Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs (Bonferroni corrected p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/aae43b64bf3e4b52b5a86a875bdab4c6 Zobrazit plný text záznamu View record in DOAJ