High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients

Autor: Morteza Naghavi, Stanley Kleis, Hirofumi Tanaka, Albert A. Yen, Ruoyu Zhuang, Ahmed Gul, Yasamin Naghavi, Ralph Metcalfe
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Vascular Medicine, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 2090-2832
DOI: 10.1155/2022/4224975
Popis: Previous studies have linked peripheral microvascular dysfunction measured by arterial tonometry to high residual risk in on-statin patients. Digital thermal monitoring (DTM) of microvascular function is a new and simplified technique based on fingertip temperature measurements that has been correlated with the burden of atherosclerosis and its risk factors. Here, we report analyses of DTM data from two large US registries: Registry-I (6,084 cases) and Registry-II (1,021 cases) across 49 US outpatient clinics. DTM tests were performed using a VENDYS device during a 5-minute arm-cuff reactive hyperemia. Fingertip temperature falls during cuff inflation and rebounds after deflation. Adjusted maximum temperature rebound was reported as vascular reactivity index (VRI). VRI distributions were similar in both registries, with mean±SD of 1.58±0.53 in Registry-I and 1.52±0.43 in Registry-II. In the combined dataset, only 18% had optimal VRI (≥2.0) and 82% were either poor (
Databáze: Directory of Open Access Journals
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