Practical guidance for clinical laboratories for SARS-CoV-2 serology testing

Autor: Carmen Charlton, Jamil Kanji, Vanessa Tran, Julianne Kus, Jonathan Gubbay, Carla Osiowy, Jason Robinson, Inna Sekirov, Michael Drebot, Todd Hatchette, Derek Stein, Nadia El-Gabalawy, Amanda Lang, Lei Jiao, Paul Levett, Heidi Wood, Christian Therrien, L Robbin Lindsay, Muhammad Morshed, Jessica Forbes, Antonia Dibernardo
Jazyk: English<br />French
Rok vydání: 2021
Předmět:
Zdroj: Canada Communicable Disease Report, Vol 47, Iss 4, Pp 171-183 (2021)
Druh dokumentu: article
ISSN: 1481-8531
DOI: 10.14745/ccdr.v47i04a01
Popis: The landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing is rapidly evolving. While serology testing has limited diagnostic capacity for acute infection, its role in providing population-based information on positivity rates and informing evidence-based decision making for public health recommendations is increasing. With the global availability of vaccines, there is increasing pressure on clinical laboratories to provide antibody screening and result interpretation for vaccinated and non-vaccinated individuals. Here we present the most up-to-date data on SARS-CoV-2 antibody timelines, including the longevity of antibodies, and the production and detection of neutralizing antibodies. Additionally, we provide practical guidance for clinical microbiology laboratories to both verify commercial serology assays and choose appropriate testing algorithms for their local populations.
Databáze: Directory of Open Access Journals