| Autor: |
J.E. Lugo, S. Mejia-Romero, R. Doti, K. Ray, S.L. Kothari, G. S. Withers, J. Faubert |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Integrative Neuroscience, Vol 17, Iss 4, Pp 323-330 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1757-448X |
| DOI: |
10.31083/j.jin.2018.04.0409 |
| Popis: |
It has been shown that competing molecular interactions of atypical protein kinase C isoforms regulate neuronal polarity. For instance, silencing one particular isoform known as protein kinase M- ζ or overexpression of a second isoform known as protein kinase C- λ in hippocampal neurons alters neuronal polarity, resulting in neurons with extra axons. In contrast, the overexpression of protein kinase M- ζ prevents axon specification. These data suggest that antagonistic competition between PKC isoforms could contribute to the development of polarity and axon specification. Here, an excitatory and inhibitory non-linear network model is employed to describe neuronal polarity under different conditions. The model shifts the balance of excitation and inhibition to replicate a variety of scenarios during axon outgrowth, which are then compared with experimental results. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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