| Autor: |
Maria F. De la Cerda-Vargas, Mattia Russel Pantalone, Cecilia Söderberg Nauclér, Rafael Medrano-Guzman, Kathrine Jauregui Renaud, Barbara Nettel Rueda, Ma de Jesus Reynoso-Sanchez, Brenda Lopez-Quintana, Marco A. Rodriguez-Florido, Iris A. Feria-Romero, Rogelio R. Trejo-Rosales, Rocio L. Arreola-Rosales, Jose A. Candelas-Rangel, Pedro Navarro-Dominguez, Elizabeth Meza-Mata, Melisa A. Muñoz- Hernandez, F.K. Segura-Lopez, Marisela Del Rocio Gonzalez-Martinez, Hector A. Delgado-Aguirre, Bayron A. Sandoval-Bonilla |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 10, Iss 7, Pp e28555- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2024.e28555 |
| Popis: |
Introduction: Previous studies have reported a correlation between a high-grade CMV-infection and an unfavorable prognosis in glioblastoma (GB). Coversely, epilepsy has been associated with a more favorable outcome in GB patients. Despites epilepsy and CMV share similar molecular mechanisms in GB tumoral microenvironment, the correlation between Tumor-Related-Epilepsy (TRE) and CMVinfection remains unexplored. The aim of our study is to examine the correlation between the dregree of CMV infection and seizure types on the survival of TRE Adult-type-diffuse-glioma. To achieve this objective, we conducted a comprehensive literature review to assess our results regarding previous publications Methods: We conducted a retrospective-observational study on TRE Adult-type-diffuse-gliomas treated at a single center in Mexico from 2010 to 2018. Tumor tissue and cDNA were analyzed by immunochemistry (IHC) for CMV (IE and LA antigens) at the Karolinska Institute in Sweden, and RT-PCR for CMV-gB in Torreon Mexico, respectively. Bivariate analysis (X2-test) was performed to evaluate the association between subtypes of Adult-type-diffuse-glioma (IDH-mut grade 4 astrocytoma vs. IDH-wt glioblastoma) and the following variables: type of hemispheric involvement (mesial vs. neocortical involvement), degree of CMV infection (25% infected-tumoral cells) and seizure types [Focal awareness, focal impaired awareness, and FBTCS]. Kaplan Meier and Cox analyses were performed to determine the risk, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
