Nanoparticle-Lipid Interaction: Job Scattering Plots to Differentiate Vesicle Aggregation from Supported Lipid Bilayer Formation

Autor: Fanny Mousseau, Evdokia K. Oikonomou, Victor Baldim, Stéphane Mornet, Jean-François Berret
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Colloids and Interfaces, Vol 2, Iss 4, p 50 (2018)
Druh dokumentu: article
ISSN: 2504-5377
DOI: 10.3390/colloids2040050
Popis: The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid interaction leads to a broad range of structures including supported lipid bilayers (SLB), particles adsorbed at the surface or internalized inside vesicles, and mixed aggregates. Currently, there is a need to have simple protocols that can readily evaluate the structures made from particles and vesicles. Here we apply the method of continuous variation for measuring Job scattering plots and provide analytical expressions for the scattering intensity in various scenarios. The result that emerges from the comparison between experiments and modeling is that electrostatics play a key role in the association, but it is not sufficient to induce the formation of supported lipid bilayers.
Databáze: Directory of Open Access Journals