Effect of Periodized Resistance Training on Skeletal Muscle During Androgen Deprivation Therapy for Prostate Cancer: A Pilot Randomized Trial
| Autor: | Jacqueline K. Dawson PhD, Tanya B. Dorff MD, Creighton Tuzon PhD, Judd C. Rice PhD, Edward Todd Schroeder PhD, Christianne J. Lane PhD, Mitchell E. Gross MD, PhD, Christina M. Dieli-Conwright PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Integrative Cancer Therapies, Vol 20 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1534-7354 1552-695X 15347354 |
| DOI: | 10.1177/15347354211035442 |
| Popis: | Purpose: Prostate cancer survivors (PCS) receive androgen deprivation therapy (ADT) as treatment for recurrent cancer, yet ADT is associated with loss of skeletal muscle and physical function. Resistance training can counter both muscle and physical function loss; however, an understanding of the molecular responses of skeletal muscle to resistance training during ADT is still undefined. This sub-analysis of the original randomized, controlled pilot trial investigated effects of 12 weeks of periodized resistance training on mRNA expression of the anabolic genes IGF-1, myogenin, PGC-1α4 and the catabolic genes myostatin and MuRF-1 in skeletal muscle of PCS on ADT. Secondary aims investigated if changes in lean mass and physical function correlated with changes in mRNA expression. Methods: PCS on ADT (n = 17) were randomized to 12 weeks of supervised resistance training (EXE, n = 9) or home-based stretching (STRETCH, n = 8) 3 days per week. Outcomes were assessed at baseline and post-intervention. Muscle biopsies were analyzed by RT-PCR for mRNA expression. Body composition was assessed through dual-energy X-ray absorptiometry, and physical function through muscular strength, timed up and go, stair climb, and 400 m walk. Results: MuRF-1 mRNA expression was significantly greater in EXE compared to STRETCH post-intervention ( P = .005). Change in MuRF-1 mRNA expression significantly correlated with improvements in strength and physical function ( P |
| Databáze: | Directory of Open Access Journals |
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