| Autor: |
Nikolić Ana, Kačar Aleksandra, Lavrnić Dragana, Basta Ivana, Apostolski Slobodan |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Srpski Arhiv za Celokupno Lekarstvo, Vol 137, Iss 11-12, Pp 594-600 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
0370-8179 |
| DOI: |
10.2298/SARH0912594N |
| Popis: |
Introduction. Diabetic polyneuropathy (DPN) is one of the most common diabetic complications, which can result in a significant functional impairment and reduction of the quality of life in affected individuals. It occurs due to alterations in different biochemical mechanisms which require the presence of thiamine, which is why this vitamin is used in the therapy of DPN. Due to the low bioavailability of the hydrosolubile forms of thiamine, its liposolubile preparations (benfotiamine) are preferentially used. Objective. The aim of this study was to determine the efficacy of benfotiamine in combination with vitamin B6 in the therapy of DPN. Methods. The study group comprised of 22 patients with DPN who were treated with the combination of benfotiamine and vitamin B6 during 45 days. The effect of the therapy was evaluated by the analysis of different clinical, laboratory and electrophysiological parameters before and after conducted treatment. Results. After the treatment period, a statistically highly significant reduction of pain (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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