Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

Autor: Rafael Ramírez-Romero, Alicia M. Nevárez-Garza, Luis E. Rodríguez-Tovar, Alfredo Wong-González, Rogelio A. Ledezma-Torres, Gustavo Hernández-Vidal
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: The Scientific World Journal, Vol 2012 (2012)
Druh dokumentu: article
ISSN: 1537-744X
DOI: 10.1100/2012/647403
Popis: Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model.
Databáze: Directory of Open Access Journals