| Autor: |
Fang Wang, Peter Breslin S J, Wei Qiu |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Liver Research, Vol 5, Iss 4, Pp 195-203 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2542-5684 |
| DOI: |
10.1016/j.livres.2021.06.001 |
| Popis: |
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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