Associations of Blood Pressure and Heart Rate and Their Contribution to the Development of Cardiovascular Complications and All-Cause Mortality in the Russian Population of 25-64 Years
| Autor: | S. A. Shalnova, V. A. Kutsenko, A. V. Kapustina, E. B. Yarovaya, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, S. A. Maksimov, G. A. Muromtseva, N. V. Kulakova, O. N. Kalachikova, T. M. Chernykh, O. A. Belova, G. V. Artamonova, E. V. Indukaeva, Yu. I. Grinshtein, R. A. Libis, D. V. Duplyakov, O. P. Rotar, I. A. Trubacheva, V. N. Serebryakova, A. Yu. Efanov, A. O. Konradi, S. A. Boytsov, O. M. Drapkina |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Рациональная фармакотерапия в кардиологии, Vol 16, Iss 5, Pp 759-769 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1819-6446 2225-3653 |
| DOI: | 10.20996/1819-6446-2020-10-02 |
| Popis: | Aim. To study the relationship of blood pressure (BP) and heart rate (HR) in a sample of men and women 25-64 years old and their predictive value for the development of fatal and non-fatal cardiovascular diseases (CVD) and mortality from all causes.Material and methods. Prospective observation was for cohorts of the population aged 25-64 years from 11 regions of the Russian Federation. 18,251 people were included in the analysis. Each participant gave written informed consent. All surveyed persons were interviewed with a standard questionnaire. BP was measured on the right hand with an automatic tonometer. BP and HR were measured twice with an interval of 2-3 min with the calculation of the average value. The patients were divided into 4 groups: the first group with BP80; the third group – BP≥140/90 mm Hg and HR≤80; the fourth group – BP≥140/90 mm Hg and HR>80 beats/min. Risk factors and cardiovascular history were analyzed as well. Deaths over 6 years of follow-up occurred in 393 people (141 – from CVD). Statistical analysis was performed using the open source R3.6.1 system.Results. A HR>80 beats/min was found in 26.3% of people with BP≥140/90 mm Hg, regardless of medication. Analysis of the associations between HR and BP showed that for every increase in HR by 10 beats/min, systolic BP increases by 3 mm Hg. (p80 beats/min and BP≥140/90 mm Hg had the shortest life expectancy (p80 beats/min in people with BP≥140 mm Hg amounted to 26.34%. Every 10 beats/min significantly increases the risk of mortality by 22%. Increased HR with elevated BP leads to increased adverse outcomes. |
| Databáze: | Directory of Open Access Journals |
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